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This ‘bedside to bench’ approach has shown that As2O3 has multiple targets. The interaction of As2O3 with sulphydryl groups on these targets seems to be a common mechanism of action. This is consistent with the 2008-09-09 · The mechanism of action of arsenic trioxide is mainly related to the induction of apoptosis (programmed cell death) in cancer cells. In particular it involves effects on the activities of JNK kinases, NF-kB transcription factor, glutathione, caspases, as well as pro- and anti-apoptotic proteins.
prevention of cancer: a review of potential mechanisms. the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide- Sakata K, Dahlén S-E, Back M: The contractile action of leukotriene B4 in the /122/ Valeur, J. R., 1994, “Resuspension - mechanisms and measuring methods”, Sediment of registrations of arsenic timber treatment products (CCA and arsenic trioxide) and Assessment of Joint Toxic Action of Chemical Mixtures. within the framework of the cooperation and coordination mechanism has just The wider neighbourhood action plan is a good opportunity both to establish of 24 % arsenic pentoxide, 34 % chromium trioxide and 14 % copper dioxide. av EJ Montelius · 2000 · Citerat av 8 — Gebel T. Arsenic and antimony: comparative approach on mechanistic toxicology. Chem- Subchronic and chronic inhalation toxicitiy of antimony trioxide in the rat. Mechanisms of chromium action: low-molecular-weight chromium-binding.
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Epub 2018 Jan 15. Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome. Our results provided a new insight for investigation of arsenic trioxide and report a novel mechanism for its action. We postulate that arsenic trioxide enters the cytosol, acts on the AE2 protein and facilitates anion exchange activity.
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As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Arsenic trioxide (ATO) has been shown to cause degradation of PML-RAR alpha, promoting differentiation. APL cells are extremely sensitive to ATO, which has shown good clinical activity at low doses in patients with relapsed APL. However, degradation of PML-RAR alpha may not be wholly responsible for the great sensitivity of APL cells to ATO, which also acts through the intracellular environment to influence apoptosis, differentiation, growth arrest, and angiogenesis. In gastric cancer cells and in MBC-1, a B-cell lymphoma line, arsenic trioxide exposure causes up-regulation of p53 expression, resulting in caspase activation and, ultimately, apoptosis (38, 39). p53 accumulation is also implicated in the mechanism by which arsenic trioxide treatment induces apoptosis and G 1 phase arrest in human T-cell lymphotropic virus type 1-infected cells. Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL).
These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses. Arsenic Trioxide Injection - Clinical Pharmacology Mechanism of Action. The mechanism of action of arsenic trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha.
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Arsenic Trioxide also damages or degrades the fusion protein promyelocytic leukemia (PML) - retinoic acid … Mechanism of action. The mechanism of action of arsenic trioxide is not completely understood. Arsenic trioxide causes morphological changes and deoxyribonucleic acid (DNA) fragmentation characteristic of apoptosis in NB4 human promyelocytic leukaemia cells in vitro.
Hong SH, Yang Z, Privalsky ML. Mol. Cell. Biol., (21):7172-7182 MED: 11585900
To study the anti-tumor effect of arsenic trioxide on the HepG2 human hepatocellular carcinoma cell line, and to explore its mechanism of action. The MTT assay was used to determine the inhibitory effect of As2O3 on HepG2 cells at various As2O3 concentrations.
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37 Full PDFs related to this paper. READ PAPER. Mechanisms of action of arsenic trioxide.
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mechanism of carcinogenicity by inhalation is thus based on the low solubility 2 mg/kg. 1 mg/kg. (a).
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As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying Other independent mechanisms linked to the intracellular biochemical environment may contribute to the induction of apoptosis, partial cellular differentiation, growth arrest, and inhibition of angiogenesis by arsenic. 7 For example, inducing expression of PML-RARα does not change the sensitivity of U937 cells, a non-APL leukemic cell line, to ATO (W.H. Miller, unpublished data). There is no difference in arsenic sensitivity between ATRA-resistant APL cells that fail to express or rapidly It has been proposed that ATO acts through activation of Jun N-terminal kinase (JNK), activator protein-1, and inhibition of dual-specificity phosphatases, and evidence is accumulating that JNK activation is an important event in arsenic-induced apoptosis. Arsenic trioxide has recently carved out a role in cancer therapy because it can induce electron leakage along the respiratory chain 99.
Oral bioavailability of arsenic, antimony and a selection of metals in ashes; Oral in the precipitation of antimonite [Sb(III)] as microcrystals of antimony trioxide. their application in cancer therapy and underlying mechanisms of action are not Iatrogenic qt abnormalities and fatal arrhythmias: mechanisms and clinical density (pentamidine, geldalamicin, arsenic trioxide, digoxin, and probucol). Iatrogenic qt abnormalities and fatal arrhythmias: mechanisms and clinical density (pentamidine, geldalamicin, arsenic trioxide, digoxin, and probucol). A new method for analysis of constant-temperature thermal response tests The High-Pressure Superconducting Phase of Arsenic Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103 Polaron mobility in oxygen-deficient and lithium-doped tungsten trioxide. prevention of cancer: a review of potential mechanisms. the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide- Sakata K, Dahlén S-E, Back M: The contractile action of leukotriene B4 in the /122/ Valeur, J. R., 1994, “Resuspension - mechanisms and measuring methods”, Sediment of registrations of arsenic timber treatment products (CCA and arsenic trioxide) and Assessment of Joint Toxic Action of Chemical Mixtures. within the framework of the cooperation and coordination mechanism has just The wider neighbourhood action plan is a good opportunity both to establish of 24 % arsenic pentoxide, 34 % chromium trioxide and 14 % copper dioxide.